Yes, you can accept Bitcoin or Ethereum payments on a Shopify store. Shopify allows you to accept cryptocurrency payments through several third-party payment processors, such as BitPay, Coinbase Commerce, and CoinPayments.

To accept cryptocurrency payments on your Shopify store, you will need to create a cryptocurrency wallet and then integrate your payment processor with your Shopify store. Once you have integrated your payment processor, you will be able to accept cryptocurrency payments on your website.